The Effect of Simultaneous Contralateral White Noise Masking on Cortical Auditory Evoked Potentials Elicited by Speech Stimuli.

Introduction Noise obscures speech signal, causing auditory masking. The effects of this masking can be observed through the cortical auditory evoked potentials (CAEPs). White noise, in turn, has an effect on the auditory cortex, interfering, for example, with lexical decision making. Objective To analyze the effect of simultaneous masking by contralateral white noise on CAEPs elicited by speech stimuli. Methods Cross-sectional observational analytical study carried out with 15 participants of both sexes, who were submitted to CAEPs in two conditions: 1) without noise; 2) with white noise at 100 dBSPL intensity, contralaterally and simultaneously. To compare these conditions, the Student t test or the Wilcoxon test were used, depending on the sample normality. Differences with p values < 0.05 were considered significant. Results : When white noise was presented contralaterally and simultaneously to the CAEPs with speech stimulus, an increase in P1, N1 and P2 wave latencies was observed. P1 and P2 amplitudes and N1-P2 peak to peak amplitude also increased, unlike N1 amplitude, which decreased. The differences were significant for P1 and P2 wave latencies and for P2 wave amplitude. Conclusion The simultaneous masking effect was observed from the morphological alterations of the CAEPs with speech stimulus when white noise was presented in the contralateral ear. There was a significant increase in P1 and P2 wave latencies, as well as in P2 wave amplitude.

Fibroma mole gigante vulvar: relato de caso / Giant soft vulvar fibroma: case report

Fibroma mole, ou pólipo fibroepitelial, é uma lesão de proporções geralmente reduzidas, de cor hiperpigmentada ou igual à da pele, localizando-se frequentemente na face, pescoço, tronco e regiões intertriginosas. É um tumor classificado como benigno e pode acometer tanto homens quanto mulheres em idade reprodutiva e depois da quarta década de vida. Ocorre principalmente em obesos, diabéticos e durante a gestação. Com menor frequência, podem alcançar dimensões que excedem 5 cm. Seu crescimento pode ser lento ou rápido e comumente são assintomáticos, mas podem promover sangramentos por conta de ulcerações decorrentes de traumas repetidos. Apresentamos neste relato um fibroma mole, gigante, de localização vulvar, com 11 cm de comprimento, 11 cm de largura e 5 cm de espessura, pesando 500 g.

Giant soft vulvar fibroma is a fibroepithelial polyp lesion with generally reduced proportions, with a hyperpigmented color or similar to that of the skin, frequently located on the face, neck, trunk and intertriginous regions. It is a tumor classified as benign, can affect both men and women, of reproductive age and after the fourth decade, mainly obese, diabetic and during pregnancy. However, less frequently, they can reach dimensions that exceed 5 cm, may have a slow or accelerated evolution. They are commonly asymptomatic, but bleeding may be present due to ulcerations resulting from repeated trauma. In the current study, we describe a giant soft fibroma with a vulvar location measuring 11 cm in length, 11 cm in width, 5 cm in thickness and weighing 500 grams.

The Effect of Different Stimulation Rates on Brainstem Auditory-Evoked-Potential Responses

Abstract Introduction Auditory-evoked potentials are influenced by several factors, including polarity, filter, stimulus intensity and stimulation rate. The presentation of higher rates of stimuli per second enables the collection of a greater number of responses in a given period of time, promoting a shorter testing time; however, the collected recordings are subject to changes related to wave morphology. Objectives To compare the brainstem auditory-evoked-potential responses with click stimulus with the most commonly used stimulation rates in the clinical practice. Methods The present cross-sectional analytical study was performed with fifteen participants of both genders and normal hearing thresholds. The brainstem auditoryevoked potential was performed at four different stimulation rates (21.1, 26.7, and 27.7 stimuli/s, and a rate determined based on a mathematical calculation using the a measurement of the transmission frequency of the power grid at the time of the examination). Results We observed that the rate of 21.1 stimuli/s showed the highest amplitudes for waves I, III, and V when compared with the other rates. The rate of 26.7 stimuli/s, when compared with 27.7 stimuli/s, showed a higher amplitude for wave V. The latency if wave V was significantly lower with the rate of 21.1 stimuli/s than with 27.7 stimuli/s. Conclusions The stimulation rate interferes with wave latencies and amplitudes; its decrease from 27.7 to 21.1 stimuli/s decreases the latency of wave V and increases the amplitues and improves the morphology of waves I, III and V. In addition, we found evidence that suggests an improvement in the visualization of wave III by adjusting the stimulation rate based on a measurement of the local transmission frequency of the power grid.

The Effect of Different Stimulation Rates on Brainstem Auditory-Evoked-Potential Responses.

Introduction Auditory-evoked potentials are influenced by several factors, including polarity, filter, stimulus intensity and stimulation rate. The presentation of higher rates of stimuli per second enables the collection of a greater number of responses in a given period of time, promoting a shorter testing time; however, the collected recordings are subject to changes related to wave morphology. Objectives To compare the brainstem auditory-evoked-potential responses with click stimulus with the most commonly used stimulation rates in the clinical practice. Methods The present cross-sectional analytical study was performed with fifteen participants of both genders and normal hearing thresholds. The brainstem auditory-evoked potential was performed at four different stimulation rates (21.1, 26.7, and 27.7 stimuli/s, and a rate determined based on a mathematical calculation using the a measurement of the transmission frequency of the power grid at the time of the examination). Results We observed that the rate of 21.1 stimuli/s showed the highest amplitudes for waves I, III, and V when compared with the other rates. The rate of 26.7 stimuli/s, when compared with 27.7 stimuli/s, showed a higher amplitude for wave V. The latency if wave V was significantly lower with the rate of 21.1 stimuli/s than with 27.7 stimuli/s. Conclusions The stimulation rate interferes with wave latencies and amplitudes; its decrease from 27.7 to 21.1 stimuli/s decreases the latency of wave V and increases the amplitues and improves the morphology of waves I, III and V. In addition, we found evidence that suggests an improvement in the visualization of wave III by adjusting the stimulation rate based on a measurement of the local transmission frequency of the power grid.

Aspectos cognitivos e auditivos: o efeito do envelhecimento no declínio do reconhecimento de fala / Cognitive and auditory aspects: the effect of aging on the decline of speech recognition / Aspectos cognitivos y auditivos: el efecto del envejecimiento sobre la disminución del reconocimiento de voz

Introdução: Dificuldades de desempenho comunicativo e de reconhecimento de fala em ambientes ruidosos são associadas ao envelhecimento. O declínio do reconhecimento da fala com ruído competitivo é devido a uma combinação de fatores auditivos e não-auditivos que acentuam ao longo do tempo e com o avanço da idade. Objetivo: Identificar os aspectos cognitivos e auditivos que contribuem para o declínio do reconhecimento de fala no ruído em idosos. Método: Trata-se de um estudo prospectivo, analítico, observacional e transversal. A amostra foi composta por dois grupos: um de adultos e outro de idosos, selecionados conforme os seguintes critérios de inclusão: ouvintes normais; idade entre 18 e 70 anos, de ambos os sexos. Os aspectos cognitivos foram analisados pelo Montreal Cognitive Assessment e, nos processos auditivos, foram aplicados testes de audiometria tonal limiar, psicofísicos de reconhecimento de fala em escuta difícil e de resolução temporal. Resultados: Quando comparados por grupo etário, os testes psicoacústicos apresentaram diferenças significativas nas condições: 1) SSI / OD - S/R 0 (p=0,001), 2) SSI / OD - S/R -15 (p=0,000), 3) HINT / OE S/R -10 (p=0,03), 5) HINT / OE S/R -15 (p= 0,02) quando aplicado o teste Mann Whitney U. Quando comparados por grupo etário, os testes GIN e TDD não apresentaram diferenças significativas. Já quando os testes psicoacústicos foram comparados independentes do grupo etário, os sujeitos com MoCA normal e alterados não apresentaram diferenças significativas (p=0,280). Conclusão: A partir da amostra estudada, observou-se que os aspectos cognitivos não contribuíram no desempenho da percepção de fala com estímulos competitivos quando comparados os grupos de adultos e idosos. Por outro lado, os aspectos auditivos avaliados mostraram que os idosos apresentam maiores dificuldades de compreensão da fala no ruído quando comparados aos indivíduos mais jovens.

Introduction: Difficulties in communicative performance and speech recognition in noise are associated with aging. The decline in speech recognition with competitive noise is due to a combination of auditory and non-auditory factors that worsens over time and with aging. Objective: To identify the cognitive and auditory aspects that contribute to the decline of speech recognition in noise in the elderly. Method: This is a prospective, analytical, observational and cross-sectional study. The sample consisted of two groups: one of adults and one of elderly, selected according to the following inclusion criteria: normal listeners; between 18 and 70 years old, of both sexes. The cognitive aspects were analyzed with the Montreal Cognitive Assessment and, in the auditory processes, pure-tone audiometry threshold tests, psychophysical speech recognition in difficult listening and temporal resolution were applied. Results: When compared by age group, psychoacoustic tests showed significant differences in conditions: 1) SSI / RE - SNR 0 (p = 0.001), 2) SSI / RE - SNR -15 (p = 0.000), 3) HINT / LE SNR -10 (p = 0.03), 5) HINT / LE SNR -15 (p = 0.02) when the Mann Whitney U test was applied. GIN and DDT tests did not show significant differences. When the psychoacoustic tests were compared regardless of the age group, the subjects with normal and changed MoCA did not present significant differences (p = 0.280). Conclusion: From the studied sample, cognitive aspects did not contribute to the performance of speech perception with competitive stimuli when comparing the adults and the elderly. On the other hand, the assessed auditory aspects showed that the elderly have greater difficulties in understanding speech in noise when compared to younger individuals.

Introducción: Las dificultades en el desempeño comunicativo y el reconocimiento del habla en entornos ruidosos están asociadas con el envejecimiento. La disminución del reconocimiento de voz con ruido competitivo se debe a una combinación de factores auditivos y no auditivos que se acentúan con el tiempo y con la edad. Objetivo: Identificar los aspectos cognitivos y auditivos que contribuyen al declive del reconocimiento del habla en ruido en las personas mayores. Método: Se trata de un estudio prospectivo, analítico, observacional y transversal. La muestra estuvo conformada por dos grupos: uno para adultos y otro para ancianos, seleccionados según los siguientes criterios de inclusión: oyentes normales; entre 18 y 70 años, de ambos los sexos. Los aspectos cognitivos fueron analizados por la Evaluación Cognitiva de Montreal y, en los procesos auditivos, se aplicaron pruebas de audiometría tonal umbral, reconocimiento psicofísico del habla en audiencias difíciles y resolución temporal. Resultados: Cuando se compararon por grupo de edad, las pruebas psicoacústicas mostraron diferencias significativas en las condiciones: 1) SSI / OD - S / R 0 (p = 0,001), 2) SSI / OD - S / R -15 (p = 0,000), 3 ) HINT/ OE S / R -10 (p = 0.03), 5) HINT / OE S / R -15 (p = 0.02) cuando se aplicó la prueba Mann Whitney U. Las pruebas GIN y TDD no mostraron diferencias significativas. Cuando se compararon las pruebas psicoacústicas independientemente del grupo de edad, los sujetos con MoCA normal y alterado no presentaron diferencias significativas (p = 0,280). Conclusión: De la muestra estudiada, se observó que los aspectos cognitivos no contribuyeron al desempeño de la percepción del habla con estímulos competitivos al comparar los grupos de adultos y ancianos. Por otro lado, los aspectos auditivos evaluados mostraron que los ancianos tienen mayores dificultades para comprender el habla en ruido en comparación con los más jóvenes.

Cognitive performance and long-latency auditory evoked potentials: a study on aging.

OBJECTIVE: To evaluate the relationship between cognitive performance and long-latency auditory evoked potentials in an elderly population. METHODS: The sample consisted of adults between 20 and 58 years of age and elderly adults between 60 and 70 years of age. The screening procedures adopted were an inspection of the external auditory canal, tonal and vocal audiometry, tympanometry, brain stem auditory evoked potential, the Montreal Cognitive Assessment test, and long-latency auditory evoked potential. RESULTS: The latency and amplitude values of cortical components by age group showed significant differences under the following conditions: (i) signals evoked by the speech stimulus /da/ and by the pure-tone stimulus at 2,000 Hz for the N2 amplitude (p=0.008 and p=0.001, respectively) , which were both higher for adults, and (ii) signals evoked by the speech stimulus /da/ for N1 latency (p=0.018) and by the pure-tone stimulus at 2,000 Hz for P2 latency (p=0.017), which were both higher in the elderly population. The cognitive component (P300) showed a significant difference when evoked by speech stimuli, with higher latency in the elderly population (p=0.013). When correlated with cognitive processes, the latency and amplitude of cortical potentials showed direct and medium-strength correlations between abnormal scores obtained on the Montreal Cognitive Assessment test and P2 amplitude (p<0.001 and r=0.452). CONCLUSION: There is a relationship between long-latency potentials and cognitive performance in the elderly, which was observed by the increase in the P2 amplitude and the impairment of the process of sound decoding.

Cognitive performance and long-latency auditory evoked potentials: a study on aging

OBJECTIVE: To evaluate the relationship between cognitive performance and long-latency auditory evoked potentials in an elderly population. METHODS: The sample consisted of adults between 20 and 58 years of age and elderly adults between 60 and 70 years of age. The screening procedures adopted were an inspection of the external auditory canal, tonal and vocal audiometry, tympanometry, brain stem auditory evoked potential, the Montreal Cognitive Assessment test, and long-latency auditory evoked potential. RESULTS: The latency and amplitude values of cortical components by age group showed significant differences under the following conditions: (i) signals evoked by the speech stimulus /da/ and by the pure-tone stimulus at 2,000 Hz for the N2 amplitude (p=0.008 and p=0.001, respectively) , which were both higher for adults, and (ii) signals evoked by the speech stimulus /da/ for N1 latency (p=0.018) and by the pure-tone stimulus at 2,000 Hz for P2 latency (p=0.017), which were both higher in the elderly population. The cognitive component (P300) showed a significant difference when evoked by speech stimuli, with higher latency in the elderly population (p=0.013). When correlated with cognitive processes, the latency and amplitude of cortical potentials showed direct and medium-strength correlations between abnormal scores obtained on the Montreal Cognitive Assessment test and P2 amplitude (p<0.001 and r=0.452). CONCLUSION: There is a relationship between long-latency potentials and cognitive performance in the elderly, which was observed by the increase in the P2 amplitude and the impairment of the process of sound decoding.

Satisfação de usuários de aparelho de amplificação sonora individual após utilização de um site responsivo no processo de adaptação / Satisfaction of users of hearing aids after using a responsive website in the adaptation process

RESUMO Objetivo O aparelho de amplificação sonora individual propicia benefícios para indivíduos com deficiência auditiva. No entanto, ainda são observados baixos níveis de adesão ao tratamento, devido às dificuldades no processo de adaptação. Neste sentido, destaca-se o uso de sites ou aplicativos com os objetivos de auxiliar no processo de orientação aos usuários e de avaliar a satisfação de usuários de aparelho de amplificação sonora individual, após a utilização de um site responsivo desenvolvido para auxiliar no processo de adaptação. Métodos Estudo quantitativo analítico experimental, ensaio clínico não randomizado, com 20 participantes, divididos em dois grupos. O grupo estudo fez uso do site responsivo como ferramenta de auxílio na adaptação, além de receber as orientações em seu formato tradicional. O grupo controle foi orientado somente pelo formato tradicional já existente no serviço. Após um mês, os participantes responderam a um questionário de avaliação de satisfação e também foi realizada a análise da ferramenta datalogging. Resultados O site responsivo contou com orientações sobre manutenção e dicas de uso do aparelho de amplificação sonora individual, permitindo fácil acesso às principais orientações ao usuário inexperiente. A análise dos dados demonstrou respostas mais positivas ao questionário pelo grupo estudo, bem como maior tempo de uso diário dos aparelhos de amplificação sonora individuais. Conclusão o grupo que utilizou o site responsivo como ferramenta complementar ao processo de adaptação do aparelho de amplificação sonora individual mostrou, a partir da avaliação da satisfação e dos dados da ferramenta datalogging, maior satisfação e maior tempo de uso diário do aparelho.

ABSTRACT Purpose The hearing aid provides benefits for individuals with hearing impairment. However, low levels of treatment adherence are still observed due to difficulties in the adaptation process. In this sense, the use of websites or applications stands out in order to assist in the process of orienting users. To evaluate the satisfaction of users of hearing aids after using a responsive website designed to assist in the adaptation process. Methods Quantitative analytical experimental study non-randomized clinical trial whit 20 participants, divided into two groups. The study group made use of the responsive website as an aid tool in adapting, in addition to also receiving the guidelines in their traditional format. The control group was guided only with the traditional format already existing in the service. After one month, the participants answered a satisfaction assessment questionnaire, as well as an analysis of the datalogging. Results The responsive website had guidance on maintenance and tips on using the individual hearing aid, allowing easy access to the main guidelines for inexperienced users. The analysis of the data showed more positive responses to the questionnaire by the study group, as well as a longer time of daily use of hearing aids. Conclusion The group that used the responsive website as a complementary tool to the adaptation process of the hearing aid showed, from the assessment of satisfaction and data from the datalogging tool, greater satisfaction and a longer time of daily use of the hearing aid.

Olfactory and taste disorders in COVID-19: a systematic review / Desordens olfativas e gustativas na COVID-19: uma revisão sistemática

Abstract Introduction: The SARS-CoV-2 virus causes COVID-19, and it is responsible for the largest pandemic since the 1918 H1N1 influenza outbreak. The classic symptoms of the disease have been well defined by the World Health Organization; however, olfactory/gustatory disorders have been reported in some studies, but there are still several missing points in the understanding and in the consensus about the clinical management of these cases. Objective: To identify evidence in the scientific literature about olfactory/gustatory disorders, their clinical presentation, prevalence and possible specific treatments associated with COVID-19. Methods: A systematic review of articles published up to April 25, 2020 was performed in Medline, Cochrane Clinical Trials, ScienceDirect, Lilacs, Scopus and Google Schoolar, OpenGrey.eu, DissOnline, The New York Academy of Medicine and Reasearch Gate. Inclusion criteria: (1) Studies on patients with COVID-19; (2) Records of COVID-19 signs/symptoms, and olfactory/gustatory functions. Exclusion criteria: (1) Studies on non-human coronavirus; (2) Review articles; (3) Experimental studies (in animals or in vitro); (4) Olfactory/gustatory disorders initiated prior to SARS-CoV-2 infection. The risk assessment of bias of the selected studies was performed using the Newcastle-Ottawa scale. Results: Six articles from the 1788 records met the inclusion criteria and were analyzed. A total of 1457 patients of different ethnicities were assessed; of them, 885 (60.7%) and 822 (56.4%) had smell and taste disorders, respectively, with women being most often affected. There were olfactory/gustatory disorders even without nasal obstruction/rhinorrhea and beginning even before the signs/symptoms of COVID-19; the recovery of smell/taste, when it occurs, usually happened in the first two weeks after COVID-19 resolution. There is evidence that olfactory/gustatory disorders are strong predictors of infection by SARS-CoV-2, and it is possible to recommend patient isolation, as early as of the medical consultation, preventing the spread of the virus. No scientific evidence has been identified for effective treatments for any of the disorders. Conclusion: Olfactory/gustatory disorders may occur at varying intensities and prior to the general symptoms of COVID-19 and should be considered as part of the clinical features of COVID-19, even in mild cases. There is still no scientific evidence of specific treatments for such disorders in COVID-19 disease.

Resumo Introdução: O vírus SARS-CoV-2 causa a COVID-19 e é responsável pela maior pandemia desde o surto de influenza H1N1 de 1918. Os sintomas clássicos da doença já foram bem definidos pela Organização Mundial da Saúde; entretanto, distúrbios olfativo-gustativos têm sido relatados em alguns estudos, mas ainda com várias lacunas no entendimento e no consenso sobre a condução clínica desses casos. Objetivo: Identificar evidências na literatura científica sobre os distúrbios olfativo-gustativos acerca da apresentação clínica, prevalência e possíveis tratamentos específicos associados à COVID-19. Método: Revisão sistemática de artigos publicados até 25 de abril de 2020 nas bases de dados: Medline, Cochrane Clinical Trials, ScienceDirect, Lilacs, Scopus e Google Schoolar, OpenGrey.eu, DissOnline, The New York Academy of Medicine e Research Gate. Foram critérios de inclusão: 1) Estudos com indivíduos com COVID-19; 2) Registro dos sinais/sintomas da COVID-19 e das funções olfativo-gustativa. Foram critérios de exclusão: 1) Estudos sobre coronavírus não humano; 2) Artigos de revisão; 3) Estudos experimentais (em animais ou in vitro); 4) Distúrbios olfativos-gustativos iniciados previamente à infecção pelo SARS-CoV-2. A avaliação de risco de viés dos estudos selecionados foi feita por meio da escala de Newcastle-Ottawa. Resultados: Seis artigos dos 1.788 registros foram selecionados. Um total de 1.457 pacientes de diversas etnias foi avaliado; desses, 885 (60,7%) apresentaram perda do olfato e 822 (56,4%) perda do paladar, sendo as mulheres as mais afetadas. Os distúrbios olfativo-gustativos estiveram presentes mesmo sem obstrução nasal/rinorreia e com início mesmo antes dos sinais/sintomas clínicos da COVID-19; a recuperação do olfato/paladar, quando ocorre, geralmente se dá nas duas primeiras semanas após a resolução da doença. Há evidências de que os distúrbios olfativo-gustativos sejam fortes preditores de infecção pelo SARS-CoV-2, podendo-se recomendar o isolamento do paciente, já a partir da consulta médica, para evitar a disseminação do vírus. Não foram identificadas evidências científicas para tratamentos eficazes para qualquer dos distúrbios. Conclusão: Podem ocorrer distúrbios olfativo-gustativos em intensidades variáveis e prévios aos sintomas gerais da COVID-19, devem ser considerados como parte dos sintomas da doença, mesmo em quadros leves. Não há ainda evidências científicas de tratamentos específicos para tais distúrbios na COVID-19.

Vestibular evoked myogenic potentials (VEMP) captured in the forearm flexor muscles: a study of its feasibility and reference ranges.

OBJECTIVE: To determine the central tendency measures and variability of vestibular evoked myogenic potential (VEMP) with regard to the latency and wave amplitude when potentials are captured from the flexor muscles of the forearm. METHODS: Ten adult volunteers with normal hearing underwent examination of their forearm flexor muscles (right and left sides; 20 samples in total) for VEMP acquisition. To this end, 200 tone burst stimuli at a 500 Hz frequency and 95 dBnHL intensity were promediated. RESULTS: No statistical differences were observed in VEMP responses acquired from the right and left forearm flexor muscles concerning P34 and N44 latencies (p=0.32 and 0.90, respectively). The mean latency obtained for the P34 wave component was 34.9 ms (±2.6), with a lower limit equal to 29.3 and an upper limit equal to 40.4 ms. The average latency of the N44 wave component was 43.6 ms (±2.1), with a lower limit of 39.1 ms and an upper limit of 48.1 ms. The results were consistent and had low variability, and showed an average asymmetry index of 15.4 (±10.7). These findings indicate that potentials may be investigated in different age groups and in specific clinical populations, such as pathologies that may alter the neuronal transmission of the inferior vestibular pathway, especially when a longer portion is observed. CONCLUSIONS: VEMP recording from forearm flexors is both feasible and stable, with latency reference ranges between 29.3 and 40.4 ms for P34, and 39.1 and 48.1 ms for N44.

Olfactory and taste disorders in COVID-19: a systematic review.

INTRODUCTION: The SARS-CoV-2 virus causes COVID-19, and it is responsible for the largest pandemic since the 1918 H1N1 influenza outbreak. The classic symptoms of the disease have been well defined by the World Health Organization; however, olfactory/gustatory disorders have been reported in some studies, but there are still several missing points in the understanding and in the consensus about the clinical management of these cases. OBJECTIVE: To identify evidence in the scientific literature about olfactory/gustatory disorders, their clinical presentation, prevalence and possible specific treatments associated with COVID-19. METHODS: A systematic review of articles published up to April 25, 2020 was performed in Medline, Cochrane Clinical Trials, ScienceDirect, Lilacs, Scopus and Google Schoolar, OpenGrey.eu, DissOnline, The New York Academy of Medicine and Reasearch Gate. INCLUSION CRITERIA: (1) Studies on patients with COVID-19; (2) Records of COVID-19 signs/symptoms, and olfactory/gustatory functions. EXCLUSION CRITERIA: (1) Studies on non-human coronavirus; (2) Review articles; (3) Experimental studies (in animals or in vitro); (4) Olfactory/gustatory disorders initiated prior to SARS-CoV-2 infection. The risk assessment of bias of the selected studies was performed using the Newcastle-Ottawa scale. RESULTS: Six articles from the 1788 records met the inclusion criteria and were analyzed. A total of 1457 patients of different ethnicities were assessed; of them, 885 (60.7%) and 822 (56.4%) had smell and taste disorders, respectively, with women being most often affected. There were olfactory/gustatory disorders even without nasal obstruction/rhinorrhea and beginning even before the signs/symptoms of COVID-19; the recovery of smell/taste, when it occurs, usually happened in the first two weeks after COVID-19 resolution. There is evidence that olfactory/gustatory disorders are strong predictors of infection by SARS-CoV-2, and it is possible to recommend patient isolation, as early as of the medical consultation, preventing the spread of the virus. No scientific evidence has been identified for effective treatments for any of the disorders. CONCLUSION: Olfactory/gustatory disorders may occur at varying intensities and prior to the general symptoms of COVID-19 and should be considered as part of the clinical features of COVID-19, even in mild cases. There is still no scientific evidence of specific treatments for such disorders in COVID-19 disease.

Effect of Forward Masking on Frequency Following Response as a Function of Age.

BACKGROUND: Forward masking occurs when noise is presented before the target signal, making the latter difficult to be perceived. It is related to temporal auditory processing and consequently to speech recognition in noisy environments, which may decline with age. Interest in forward masking has grown in the last years. Studies investigate psychoacoustic and electrophysiological recordings in different age- groups. PURPOSE: The purpose of the study was to investigate the effect of forward masking on frequency following response (FFR) as a function of age. RESEARCH DESIGN: Cross-sectional analytical observational study. STUDY SAMPLE: We assessed 69 normal-hearing participants of both genders assigned to three groups: 40 young individuals (aged 18-25 years, mean age = 22 years 8 months), 21 middle-age individuals (aged 25-55 years, mean age = 37 years 2 months), and 8 seniors (aged <55 years, mean age = 65 years 3 months). INTERVENTION: FFRs were recorded using the /da/ syllable with and without noise. DATA COLLECTION AND ANALYSIS: The /da/ syllable and speech-shaped noise were monaurally presented to the participants' right ears through ER-3a insert earphones. Electrodes were placed in M1 and M2 (-), Fz (+), and Fpz (ground). Acquisition occurred under two conditions: (1) the/da/ syllable presented without the noise and (2) the /da/ syllable presented 4 msec after the noise. RESULTS: Data show that (1) considering the mean values of all participants, there was a significant latency delay of all waves (PV, A, PW, PX, PY, PZ, and O) when the /da/ syllable was presented 4 msec after the masking noise as compared with the condition without noise, that is, forward masking occurred in all components of the FFR responses, and (2) for the youngest group and the middle-age group, forward masking was seen for all waves, except PX in the latter one; for the senior group, an irregular pattern was observed (presence of forward masking in PA, PY, PZ, and O). This pattern may be due to an aging effect on FFR responses even without noise presence, which makes it more difficult to identify forward masking effect in this population. Although it is well documented in the literature that forward masking increases with age, this is less evident on FFR recordings in the senior population. CONCLUSIONS: An aging effect was identified in FFR responses. Forward masking was identified in FFR responses of all groups but less evident in senior population.

Vestibular evoked myogenic potentials (VEMP) captured in the forearm flexor muscles: a study of its feasibility and reference ranges

OBJECTIVE: To determine the central tendency measures and variability of vestibular evoked myogenic potential (VEMP) with regard to the latency and wave amplitude when potentials are captured from the flexor muscles of the forearm. METHODS: Ten adult volunteers with normal hearing underwent examination of their forearm flexor muscles (right and left sides; 20 samples in total) for VEMP acquisition. To this end, 200 tone burst stimuli at a 500 Hz frequency and 95 dBnHL intensity were promediated. RESULTS: No statistical differences were observed in VEMP responses acquired from the right and left forearm flexor muscles concerning P34 and N44 latencies (p=0.32 and 0.90, respectively). The mean latency obtained for the P34 wave component was 34.9 ms (±2.6), with a lower limit equal to 29.3 and an upper limit equal to 40.4 ms. The average latency of the N44 wave component was 43.6 ms (±2.1), with a lower limit of 39.1 ms and an upper limit of 48.1 ms. The results were consistent and had low variability, and showed an average asymmetry index of 15.4 (±10.7). These findings indicate that potentials may be investigated in different age groups and in specific clinical populations, such as pathologies that may alter the neuronal transmission of the inferior vestibular pathway, especially when a longer portion is observed. CONCLUSIONS: VEMP recording from forearm flexors is both feasible and stable, with latency reference ranges between 29.3 and 40.4 ms for P34, and 39.1 and 48.1 ms for N44.

Fones de ouvido supra-aurais e intra-aurais: um estudo das saídas de intensidade e da audição de seus usuários / Supra and intra-aural earphones: a study of output intensity and hearing levels of their users

RESUMO Introdução A perda auditiva ocasionada pelo uso inadequado de aparelhos amplificadores, como smartphones, vem crescendo rapidamente. Objetivo Mensurar e analisar as intensidades máximas e equivalentes de saída dos fones supra-aurais e intra-aurais, comparar as intensidades equivalentes e máximas ajustadas entre os dois tipos de fones e correlacionar o tempo de uso, a intensidade de uso e a média de 500 Hz, 1000 Hz e 2000 Hz e o limiar de reconhecimento de fala. Métodos A amostra foi composta por 20 sujeitos de ambos os gêneros, com faixa etária de 16 a 27 anos. As análises dos resultados foram realizadas por orelha, totalizando 40 orelhas. Os procedimentos adotados foram: aplicação de questionário, inspeção do conduto auditivo externo, audiometria tonal e vocal, imitanciometria e avaliação das intensidades de saída dos fones supra-aurais e intra-aurais. Resultados Os fones supra-aurais possuíam saídas com intensidades equivalentes e máximas significativamente maiores que os intra-aurais. Quando comparadas as intensidades máximas ajustadas, constatou-se que os usuários de fones intra-aurais utilizaram saídas com intensidades equivalentes e máximas significativamente maiores que os usuários de fones supra-aurais, observando-se uma correlação de média força entre o tempo de uso e o uso diário, na frequência isolada de 3000 Hz. Conclusão Os fones supra-aurais possuem saídas com intensidades equivalentes e máximas maiores que os fones intra-aurais, na execução de uma música. Os usuários de fones intra-aurais utilizam saídas com intensidades equivalentes e máximas maiores que os usuários de fones supra-aurais. Os sujeitos que ouvem música com mais frequência, as ouvem por menos tempo ao longo do dia, porém, com a maior intensidade.

ABSTRACT Introduction Hearing loss caused by the improper use of amplifying devices such as smartphones has been growing rapidly. Purpose Measure and analyze the maximum and equivalent output intensities of supra-aural and intra-aural headphones, compare the adjusted intensities and correlate time and intensity of use, average frequencies of 500 Hz, 1000 Hz and 2000 Hz and the speech recognition threshold. Methods The sample consisted of 20 subjects from both sexes, between the age of 16 and 27 years. The results were analyzed per ear, totaling 40 ears. The following procedures were adopted: questionnaire application, inspection of the ear canal, tonal and vocal audiometry, impedance testing and assessment of output intensities of supra-aural and intra-aural headphones. Results Supra-aural headphones have significantly higher equivalent and maximum output intensities compared to their intra-aural counterparts. When adjusted maximum intensities were compared, it was found that intra-aural headphone users used significantly higher equivalent and maximum output intensities than supra-aural headphones users, showing a moderate correlation between time of use and daily use at a frequency of 3000 Hz. Conclusion During the playing of a song, supra-aural headphones have outputs with greater equivalent and maximum intensities than intra-aural headphones. Intra-aural headphone users use higher equivalent and maximum output intensities than users of supra-aural headphones. Subjects that listen to music often do so for less time during the day, but at greater intensity.

Potencial evocado auditivo de estado estável em frequências portadoras acima de 4000 Hz / Auditory steady-state evoked potentials at carrier frequencies above 4000 Hz

RESUMO Introdução O potencial evocado auditivo de estado estável (PEAEE) tem sido apontado como uma técnica promissora para avaliar a audição de pacientes que não cooperam espontaneamente na determinação dos limiares auditivo. Embora estudos relatem desempenho diminuído nas frequências portadoras acima de 4000 Hz, são necessários avanços técnicos para determinar a sua utilidade clínica, pois o uso dessas frequências pode contribuir para um melhor diagnóstico audiológico. Objetivo Analisar os potenciais evocados auditivos de estado estável, em frequências portadoras acima de 4000 Hz. Métodos A avaliação dos PEAEE foi realizada de forma isolada e combinada, nas intensidades de 50 dBNPSpe e 80 dBNPSpe, nas frequências portadoras de 6000 e 8000 Hz, com o sistema de aquisição e análise MASTER. Resultados Foi realizada análise de variância (ANOVA two-way), em que se encontrou diminuição das amplitudes, quando relacionadas às intensidades e às condições do estímulo. Conclusão Foi possível avaliar as frequências portadoras de 6000 e 8000 Hz, tanto de forma isolada, quanto combinada. Não houve interações entre as frequências portadoras de 6000 Hz e 8000 Hz, quanto à forma de apresentação (combinada e isolada) e intensidade, para a amostra estudada.

ABSTRACT Introduction The auditory steady-state evoked potentials (ASSEPs) has been identified as a promising technique for assessing hearing in patients who do not cooperate spontaneously in determining auditory thresholds. Although studies report decreased performance at carrier frequencies above 4000 Hz , technical advancements to determine its clinical utility is necessary because the use of these frequencies can contribute to a better audiological diagnosis. Purpose Aimed to analyze the general auditory steady-state response at carrier frequencies above 4000Hz. Methods Evaluation of ASSEPs combined and isolated at the intensities of 50 SLPpe and 80 SLPpe at the carrier frequencies 6000 Hz to 8000 Hz, with the signal acquisition and analysis system MASTER. Results Analysis of variance (two-way ANOVA), which found decreased amplitudes when related to the intensity and the stimulus conditions. Conclusion It was possible to evaluate the carrier frequencies 6000 Hz and 8000 Hz, either alone or combined. There were no interactions between the carrier frequencies 6000 Hz to 8000 Hz in both forms of presentation (combined and isolated) and intensity, for the sample.

Positioning of earphones and variations in auditory thresholds, / O posicionamento dos fones de ouvido e as variações dos limiares auditivos

ABSTRACT INTRODUCTION: One of the problems observed in pure-tone audiometry tonal has been the variation in test results of a same individual, particularly at frequencies of 4 kHz, 6 kHz and/or 8 kHz. Improper placement of headphones is one of the factors that can cause alterations in results. OBJECTIVE: To compare differences in auditory thresholds using earphones positioned by the examiner and by the worker. METHODS: Clinical and experimental study conducted in 2009, with 324 workers aged between 19 and 61 years, with a mean of 33.29 years and mean exposure time of 7.67 years. All subjects were familiar with audiometry procedures. Auditory thresholds were obtained at frequencies of 0.25-8 kHz, with earphones positioned by the examiners, and at frequencies of 4, 6 and 8 kHz, with earphones placed by workers in a comfortable position, following the examiner's instructions. The thresholds obtained in these two situations were compared. RESULTS: The three frequencies exhibited better responses with earphones placed by the workers themselves (p < 0.001). At a frequency of 8 kHz a greater difference was found (p < 0.001), with a mean of 13.89 dB and standard deviation of 6.07 dB. CONCLUSION: Earphone placement by the workers themselves under supervision of the examiner results in improved mean auditory thresholds at frequencies of 4, 6 and 8 kHz, the last one significantly higher than the other two.

RESUMO INTRODUÇÃO: Um dos problemas observados na audiometria tonal é a variação nos resultados de testes de um mesmo indivíduo, sobretudo nas frequências de 4, 6 e/ou 8 kHz. A colocação indevida dos fones é um dos fatores que podem causar alterações nos resultados. OBJETIVO: Comparar as diferenças nos limiares auditivos com os fones posicionados pelo examinador e pelo paciente. MÉTODO: Estudo clínico e experimental realizado, em 2009, com 324 trabalhadores, com idade entre 19 e 61 anos, média de 29,33 anos e tempo médio de exposição ao ruído de 7,67 anos; todos familiarizados com os procedimentos da audiometria. Os limiares auditivos foram obtidos nas frequências de 0,25 a 8 kHz, com os fones colocados pelos examinadores; e nas frequências de 4, 6 e 8 kHz com os fones colocados pelos trabalhadores em posição de conforto, sob orientação do examinador. Os limiares obtidos nas duas situações foram comparados. RESULTADOS: As três frequências apresentaram melhores respostas com os fones colocados pelos próprios indivíduos (p < 0,001). Na frequência de 8 kHz foi encontrada a maior diferença (p < 0,001), com média de 13,89 dB e desvio padrão de 6,07 dB. CONCLUSÃO: A colocação dos fones de ouvido pelos próprios trabalhadores, sob supervisão dos examinadores, resulta na melhora dos limiares auditivos médios nas frequências de 4, 6 e 8 kHz, sendo esta última significativamente maior que as demais.

Positioning of earphones and variations in auditory thresholds.

INTRODUCTION: One of the problems observed in pure-tone audiometry tonal has been the variation in test results of a same individual, particularly at frequencies of 4kHz, 6kHz and/or 8kHz. Improper placement of headphones is one of the factors that can cause alterations in results. OBJECTIVE: To compare differences in auditory thresholds using earphones positioned by the examiner and by the worker. METHODS: Clinical and experimental study conducted in 2009, with 324 workers aged between 19 and 61 years, with a mean of 33.29 years and mean exposure time of 7.67 years. All subjects were familiar with audiometry procedures. Auditory thresholds were obtained at frequencies of 0.25-8kHz, with earphones positioned by the examiners, and at frequencies of 4, 6 and 8kHz, with earphones placed by workers in a comfortable position, following the examiner's instructions. The thresholds obtained in these two situations were compared. RESULTS: The three frequencies exhibited better responses with earphones placed by the workers themselves (p<0.001). At a frequency of 8kHz a greater difference was found (p<0.001), with a mean of 13.89dB and standard deviation of 6.07dB. CONCLUSION: Earphone placement by the workers themselves under supervision of the examiner results in improved mean auditory thresholds at frequencies of 4, 6 and 8kHz, the last one significantly higher than the other two.

The importance of electrically evoked stapedial reflex in cochlear implant.

INTRODUCTION: The most important stage in fitting a cochlear implant is the identification of its dynamic range. The use of objective measures, in particular the electrically elicited stapedius reflex, may provide suitable assistence for initial fitting of cochlear implant, especially in children or adult with multiple disorders, because they provide specific values that serve as the basis of early cochlear implant programming. OBJECTIVE: Verify through a review the use of the electrically elicited stapedius reflex threshold during the activation and mapping process of cochlear implant. METHODS: Bibliographical search on the Pubmed and Bireme plataforms, and also on Medline, LILACS and SciELO databases, with standard searches until September 2012, using specific keywords. For the selection and evaluation of scientific studies found in the search, criterias have been established, considering the following aspects: author, year/location, grade of recommendation/level of evidence, purpose, sample, age, mean age in years, evaluative testing, results and conclusion. RESULTS: Among 7,304 articles found, 7,080 were excluded from the title, 152 from the abstract, 17 from the article reading, 43 were repeated and 12 were selected for the study. CONCLUSION: The electrically elicited stapedius reflex may support when programming the cochlear implant, especially in patients with inconsistent responses.

Sound localization and occupational noise.

OBJECTIVE: The aim of this study was to determine the effects of occupational noise on sound localization in different spatial planes and frequencies among normal hearing firefighters. METHOD: A total of 29 adults with pure-tone hearing thresholds below 25 dB took part in the study. The participants were divided into a group of 19 firefighters exposed to occupational noise and a control group of 10 adults who were not exposed to such noise. All subjects were assigned a sound localization task involving 117 stimuli from 13 sound sources that were spatially distributed in horizontal, vertical, midsagittal and transverse planes. The three stimuli, which were square waves with fundamental frequencies of 500, 2,000 and 4,000 Hz, were presented at a sound level of 70 dB and were randomly repeated three times from each sound source. The angle between the speaker's axis in the same plane was 45°, and the distance to the subject was 1 m. RESULT: The results demonstrate that the sound localization ability of the firefighters was significantly lower (p<0.01) than that of the control group. CONCLUSION: Exposure to occupational noise, even when not resulting in hearing loss, may lead to a diminished ability to locate a sound source.